Spermidine: A Physiological Autophagy Inducer Acting as an Anti-Aging Vitamin in Humans?

Conducted by Frank Madeo, Maria A. Bauer, Didac Carmona-Gutierrez, and Guido Kroemer, this article discusses nutritional and other possible routes to counteract the age-mediated decline of spermidine levels. They also claimed that “External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine concentrations and age-related deterioration has been suggested.”