Induction of Autophagy by Spermidine Promotes Longevity

In a study conducted by 29 researchers, the longevity effects of spermidine were explored. It reported that the administration of spermidine extends the lifespan of yeast, flies, worms, and human immune cells. Additionally, they found that enhanced autophagy, which is induced through the consumption of spermidine, is crucial for polyamine-induced suppression of necrosis and enhanced longevity. The results of the study show that a decrease in polyamines has been repeatedly correlated with the aging process.