Effects of Spermidine on Gut Microbiota Modulation in Experimental Abdominal Aortic Aneurysm Mice

A study published in Nutrients (2022) uncovered significant alteration to gut microbiota composition and function in an experimental abdominal aortic aneurysm (AAA) mouse model. Exogenous spermidine, administrated via drinking water, attenuated the progression of AAA (thought to be due to alleviating inflammation) and restored gut microbiota homeostasis.

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Elevation of Serum Spermidine in Obese Patients: Results from a Cross-Sectional and Follow-Up Study

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Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression