Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model

Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer’s disease (AD). Impairment of autophagy has been identified as another important feature contributing to Alzheimer’s disease progression. In this paper published in the Journal of Neurology (2022), oral treatment of the AD-like APPPS1 mice with autophagy-activating spermidine reduced neurotoxic soluble Aβ and decreased AD-associated neuroinflammation. Spermidine seems to be an attractive therapeutic dietary supplement as it attenuated AD-relevant changes with no adverse effects.