Spermidine supplementation influences mitochondrial number and morphology in the heart of aged mice

In this paper first published in 2021 in the Journal of Anatomy, researchers looked at the mitochondria of the aged mouse left ventricle, which exhibited changes in number and 3D ultrastructure that is likely the structural correlate of dysfunctional mitochondrial dynamics. Spermidine treatment reduced, at least in part, these morphological changes, indicating a beneficial effect on cardiac mitochondrial alterations associated with aging.