A systematic exploration reveals the potential of spermidine for hypopigmentation treatment through the stabilization of melanogenesis-associated proteins

A 2022 study published in Scientific Reports by Brito et al investigated the role of spermidine in the production of melanin pigments. Spermidine treatment increased melanin production in melanocytes in a dose dependent manner. When spermidine was applied to a human skin equivalent, the researchers observed elevated melanin production. Their results identify spermidine as a potential natural product to alleviate hypopigmentation or inadequate pigmentation of the skin.