Non-linear association between serum spermidine and mild cognitive impairment: Results from a cross-sectional and longitudinal study

Xu et al (2022) conducted a cross-sectional and longitudinal study including a baseline survey from June to August 2019 and one follow-up survey from June 2021 to August 2021. They analyzed the serum spermidine levels of 3,774 adult participants aged >35 years who had no history of dementia. In line with cross-sectional findings, the longitudinal study showed that a high serum spermidine concentration may indicate a lower risk of mild cognitive impairment (MCI). They suggest that monitoring spermidine levels may help reduce the incidence and burden of MCI.