Spermidine and cardiovascular disease

The purpose of this epidemiological study, conducted by the Jichi Medical University, was to examine the contribution of dietary polyamines including spermidine toward preventing cardiovascular disease (CVD). The results showed that polyamines including spermidine had significantly negative associations with CVD, meaning a higher intake of spermidine may lead to a lower likeliness of contracting a CVD. The study stated “Polyamine is indispensable not only for cell growth and differentiation but also for cell function. In addition, polyamine from extracellular sources exerts strong anti-inflammatory properties.”