The effect of spermidine on memory performance in older adults at risk for dementia

In this randomized controlled trial, cognitively intact participants with subjective cognitive decline were included in this three-month, placebo-controlled trial with a spermidine-rich plant extract supplement. Memory performance was moderately enhanced in the spermidine group compared with placebo at the end of intervention and nutritional spermidine was associated with a positive impact on memory performance in older adults with subject cognitive decline. The beneficial effect might be mediated by stimulation of neuromodulatory actions in the memory system. A follow-up Phase IIb randomized controlled trial helped validate the therapeutic potential of spermidine supplementation and delineate possible neurophysiological mechanisms of action.