Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy

This study, conducted by 5 researchers, concluded that spermidine reduces lipid accumulation and neurotic core formation in atherosclerotic plaques in mice. Additionally, spermidine reduces lipid accumulation in vascular smooth muscle cells and also mediates cholesterol efflux in vascular smooth muscle cells by the induction of autophagy. Ultimately, it stated that spermidine’s autophagy induction may be used to prevent vascular disease.