Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression

Autophagy is required for oogenesis and plays a critical role in response to aging caused by oxidative stress. However, there have been no reports on regulation of cytoprotective autophagy in female germline stem cells (FGSCs) in response to aging caused by oxidative stress until now.

Spermidine induces cytoprotective autophagy in FGSCs in vitro and ameliorates cellular senescence of FGSCs induced by H2O2. Furthermore, Spermidine can ameliorate cellular senescence of FGSCs through p62. Spermidine might induce autophagy in FGSCs via the PI3K/Akt pathway. The findings of this 2021 study could be helpful for delaying aging of female germ cells due to oxidative stress and preserving female fertility.